Great River Road: Wisconsin to Galena
WIS 35 along the Upper Mississippi bluffs, from Prescott to Galena, through river towns and state parks.
- Distance
- 242 miles
- Driving
- 7 hours
- Take
- 3 days
- Route
- Prescott, WI to Galena, IL
The Great River Road follows the Mississippi through Wisconsin on WIS 35, with bluffs on one side and barge channels on the other. Maiden Rock, Alma, Trempealeau and La Crosse come early; Prairie du Chien and Cassville follow, then Galena just over the Illinois line. Wyalusing and Perrot state parks give views of the river. It suits cyclists, birders and fall drivers.
The stops
Start
Prescott, WI
Town
Prescott
Where the St. Croix meets the Mississippi.
Viewpoint
Maiden Rock
Bluff overlooking Lake Pepin.
Town
Alma
Single-street river town; climb Buena Vista Park for the view.
Town
Trempealeau
River village next to Perrot State Park.
Park
Perrot State Park
Bluff trails above the river.
Town · Overnight
La Crosse
Biggest city on the route; good for lunch.
Town
Genoa
Tiny town with a fish hatchery and lock and dam.
Town
Prairie du Chien
Historic fur-trade town.
Park
Wyalusing State ParkRiver overlook where the Wisconsin joins the Mississippi.
Town
Cassville
Ferry and Stonefield Historic Site nearby.
Town · Overnight
GalenaWell-preserved 19th-century downtown on a hillside.
Finish
Galena, IL
Where to stay
Night 1
La Crosse
Perrot State Park campground · La Crosse hotels
Night 2
Prairie du Chien
Wyalusing State Park campground · Prairie du Chien motels
Night 3
Galena
Galena inns and B&Bs · Chestnut Mountain Resort area
- When to go
- Sep–Oct for foliage and eagles; May–Jun for wildflowers
- On the road
- Floods occasionally close sections; check state DOT. Bald eagle watching is best in winter near locks and dams.
Take the trip with you
Roadtrip finds the cheapest fuel on the way, warns you about tolls and cameras, and splits the cost with everyone in the car.
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