Great River Road: Wisconsin to Galena

WIS 35 along the Upper Mississippi bluffs, from Prescott to Galena, through river towns and state parks.

Distance
242 miles
Driving
7 hours
Take
3 days
Route
Prescott, WI to Galena, IL
Plan this trip for your car

The Great River Road follows the Mississippi through Wisconsin on WIS 35, with bluffs on one side and barge channels on the other. Maiden Rock, Alma, Trempealeau and La Crosse come early; Prairie du Chien and Cassville follow, then Galena just over the Illinois line. Wyalusing and Perrot state parks give views of the river. It suits cyclists, birders and fall drivers.

The stops

  1. Start

    Prescott, WI

  2. Town

    Prescott

    Where the St. Croix meets the Mississippi.

  3. Viewpoint

    Maiden Rock

    Bluff overlooking Lake Pepin.

  4. Town

    Alma

    Single-street river town; climb Buena Vista Park for the view.

  5. Town

    Trempealeau

    River village next to Perrot State Park.

  6. Park

    Perrot State Park

    Bluff trails above the river.

  7. Town · Overnight

    La Crosse

    Biggest city on the route; good for lunch.

  8. Town

    Genoa

    Tiny town with a fish hatchery and lock and dam.

  9. Town

    Prairie du Chien

    Historic fur-trade town.

  10. Park

    Wyalusing State Park

    River overlook where the Wisconsin joins the Mississippi.

  11. Town

    Cassville

    Ferry and Stonefield Historic Site nearby.

  12. Town · Overnight

    Galena

    Well-preserved 19th-century downtown on a hillside.

  13. Finish

    Galena, IL

Where to stay

  • Night 1

    La Crosse

    Perrot State Park campground · La Crosse hotels

  • Night 2

    Prairie du Chien

    Wyalusing State Park campground · Prairie du Chien motels

  • Night 3

    Galena

    Galena inns and B&Bs · Chestnut Mountain Resort area

When to go
Sep–Oct for foliage and eagles; May–Jun for wildflowers
On the road
Floods occasionally close sections; check state DOT. Bald eagle watching is best in winter near locks and dams.

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